Founded in 1963, the Home was a small, clapboard residence near the railroad tracks on Duke Street in Alexandria, Virginia. Abandoned and in poor shape, the house was repaired and soon housed four residents and a resident manager.

In 1964, "Robbie" Robinson, a local businessman and philanthropist, made it possible for the Women's Home to move to, and later purchase, a small Cape Cod style house in Arlington, where it remained for the next 21 years. During these years, the Women's Home won respect and admiration in the community and among professionals.

To accommodate the growing number of deserving applicants, the Women's Home sold its longstanding residence in 1985 and purchased a larger house, also located in Arlington, close to Virginia Hospital Center (formerly Arlington Hospital), where it is located today.

In 2013, the Home celebrated its 50th anniversary of providing affordable long-term residential services for women from all walks of life who are recovering from alcohol or substance abuse.